Forebrain Acetylcholine Modulates Isoflurane and Ketamine Anesthesia in Adult Mice
نویسندگان
چکیده
Background Cholinergic drugs are known to modulate general anesthesia, but anesthesia responses in acetylcholine-deficient mice have not been studied. It was hypothesized that with genetic deficiency of forebrain acetylcholine show increased anesthetic sensitivity isoflurane and ketamine decreased gamma-frequency brain activity. Methods Male adult heterozygous knockdown vesicular transporter the or homozygous knockout basal were compared wild-type mice. Hippocampal frontal cortical electrographic activity righting reflex studied response doses. Results The loss-of-righting-reflex dose for lower (mean ± SD, 0.76 0.08%, n = 18, P 0.005) (0.78 0.07%, 24, 0.021), as (0.83 23), using a significance criterion 0.017 three planned comparisons. Loss-of-righting-reflex (144 39 mg/kg, 14, 0.006) (162 32 20, 0.602) (168 24 21). high-gamma (63 100 Hz) power after significantly (isoflurane-dose mouse-group interaction effect, F[8,56] 2.87, 0.010; 5 6 per group). both when (interaction effect F[2,13] 6.06, 0.014). change gamma statistically different among knockout, knockdown, Conclusions These findings suggest cholinergic neurons behavioral hippocampal during anesthesia. Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2021
ISSN: ['0003-3022', '1528-1175']
DOI: https://doi.org/10.1097/aln.0000000000003713